| http://purl.uniprot.org/citations/16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16517010 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of natriuretic peptide receptor-A (NPRA) produces the second messenger cGMP, which plays a pivotal role in maintaining blood pressure and cardiovascular homeostasis. In the present study, we have examined the role of trans-acting factor Ets-1 in transcriptional regulation of Npr1 gene (coding for NPRA). Using deletional analysis of the Npr1 promoter, we have defined a 400 base pair (bp) region as the core promoter, which contains consensus binding sites for transcription factors including: Ets-1, Lyf-1, and GATA-1/2. Overexpression of Ets-1 in mouse mesangial cells (MMCs) enhanced Npr1 gene transcription by 12-fold. However, overexpression of GATA-1 or Lyf-1 repressed Npr1 basal promoter activity by 50% and 80%, respectively. The constructs having a mutant Ets-1 binding site or lacking this site failed to respond to Ets-1 activation of Npr1 gene transcription. Collectively, the present results demonstrate that Ets-1 greatly stimulates Npr1 gene promoter activity, implicating its critical role in the regulation and function of NPRA at the molecular level."xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2006.01.004"xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/author | "Kumar P."xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/author | "Pandey K.N."xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/author | "Arise K.K."xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/pages | "1762-1769"xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/title | "Transcriptional regulation of guanylyl cyclase/natriuretic peptide receptor-A gene."xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/16517010 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16517010 |
| http://purl.uniprot.org/citations/16517010 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16517010 |
| http://purl.uniprot.org/uniprot/#_E9PWI8-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q540Q5-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q2TAY4-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q3UY30-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q6R5C9-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_P18293-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_P27577-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q8K3Q9-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q91X04-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q921D8-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q8BVW8-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |
| http://purl.uniprot.org/uniprot/#_Q6TDG7-mappedCitation-16517010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517010 |