| http://purl.uniprot.org/citations/16517599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16517599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16517599 | http://www.w3.org/2000/01/rdf-schema#comment | "The specific post-translational modifications of the histone proteins are associated with specific DNA-templated processes, such as transcriptional activation or repression. To investigate the biological role(s) of histone H4 lysine 20 (H4 Lys-20) methylation, we created a novel panel of antibodies that specifically detected mono-, di-, or trimethylated H4 Lys-20. We report that the different methylated forms of H4 Lys-20 are compartmentalized within visually distinct, transcriptionally silent regions in the mammalian nucleus. Interestingly, direct comparison of methylated H4 Lys-20 with the different methylated states of histone H3 lysine 9 (H3 Lys-9) revealed significant overlap and exclusion between the specific groups of methyl modifications. Trimethylated H4 Lys-20 and H3 Lys-9 were both selectively enriched within pericentric heterochromatin. Similarly, monomethylated H4 Lys-20 and H3 Lys-9 partitioned together and the dimethylated forms partitioned together within the chromosome arms; however, the mono- and dimethylated modifications were virtually exclusive. These findings strongly suggest that the combinatorial presence or absence of the different methylated states of H4 Lys-20 and H3 Lys-9 define particular types of silent chromatin. Consistent with this, detailed analysis of monomethylated H4 Lys-20 and H3 Lys-9 revealed that both were preferentially and selectively enriched within the same nucleosome particle in vivo. Collectively, these findings define a novel trans-tail histone code involving monomethylated H4 Lys-20 and H3 Lys-9 that act cooperatively to mark distinct regions of silent chromatin within the mammalian epigenome."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m513462200"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m513462200"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Rice J.C."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Rice J.C."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Houston S.I."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Houston S.I."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Magazinnik T."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Magazinnik T."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Sims J.K."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/author | "Sims J.K."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/pages | "12760-12766"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/pages | "12760-12766"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/title | "A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/title | "A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin."xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16517599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16517599 |
| http://purl.uniprot.org/citations/16517599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16517599 |