| http://purl.uniprot.org/citations/16517735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16517735 | http://www.w3.org/2000/01/rdf-schema#comment | "The spontaneous crescentic glomerulonephritis-forming/Kinjoh (SCG/Kj) mouse is a model of human crescentic glomerulonephritis and vasculitis associated with the production of the myeloperoxidase (MPO)-specific antineutrophil cytoplasmic autoantibody (MPO-ANCA). Although the disease is mediated initially by mutation of the Fas gene (lpr), SCG/Kj mice also have non-Fas predisposing genetic factors. To define these factors, genome-wide quantitative trait locus (QTL) mapping was performed on female (B(6)x SCG/Kj) F(2) intercross mice. Fourteen non-Fas QTLs were identified. QTLs of glomerulonephritis were located on chromosomes 1, 10, 13, 16, and 17, vasculitis on chromosomes 1 and 17, splenomegaly on chromosome 1, hypergammaglobulinemia on chromosomes 1, 2, 4, 6, 7, 11, 13, and 17, antinuclear Ab on chromosomes 1, 8, 10, and 12, and MPO-ANCA production on chromosomes 1 and 10. Significant QTLs derived from SCG/Kj on chromosomes 1, 2, 7, and 13 were designated Scg-1 to Scg-5, respectively, and those derived from B(6) on chromosomes 4, 6, 17, and 10 were designated Sxb-1 to Sxb-4, respectively. Two loci linked to MPO-ANCA production on chromosomes 1 and 10 were designated Man-1 and Man-2 (for MPO-ANCA), respectively. Although both Scg-1 and Scg-2 were on chromosome 1 and shared several functions, it was of interest that aberrant MPO-ANCA production was exclusively controlled by Man-1, the centromeric half region of the Scg-2 chromosomal segment. We also examined the epistatic effects between the lpr mutation and non-Fas susceptibility genes. QTLs are discussed in relation to previously described loci, with emphasis on their candidate genes."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.6.3662"xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Nishimura H."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Matsuoka S."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Suzuki K."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Tsukamoto K."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Tanaka M."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Hirose S."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Tachikawa H."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Hamano Y."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Sun G.D."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Tokunaka K."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/author | "Ishida-Okawara A."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/pages | "3662-3673"xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/title | "Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice."xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16517735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16517735 |
| http://purl.uniprot.org/citations/16517735 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16517735 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ27-mappedCitation-16517735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16517735 |