| http://purl.uniprot.org/citations/16519896 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16519896 | http://www.w3.org/2000/01/rdf-schema#comment | "Given the well-defined role of LIM-motif containing proteins in cytoskeletal organization, cell fate, and differentiation, we hypothesized that the regulation of LIM proteins played an integral role in vascular remodeling. We screened a compendium of cDNA microarray data from rat vascular smooth muscle cells (VSMC) for novel LIM-containing targets and identified muscle LIM protein (MLP), a gene previously thought to be only in striated muscle. Sequence analysis, RTQPCR and Western blotting reconfirmed expression of MLP in VSMC. MLP was elevated>10-fold 7 days following balloon injury in the rat carotid artery. Wire injury led to a significantly increased intima/media ratio in MLP -/-mice compared to wild-type controls (P<0.007, N=5). Fas-ligand and ceramide-induced apoptosis were significantly decreased in MLP deficient VSMC (n=6, P<0.001). Adenoviral-induced restoration of MLP significantly restored apoptotic response (N=6, P<0.001). These findings are the first to identify MLP in vascular smooth muscle and demonstrate that it plays a critical role in vascular remodeling. This is consistent with earlier findings demonstrating a role for MLP in striated muscle remodeling in response to load and stretch."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2006.01.005"xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/author | "Hall J.L."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/author | "Adhikari N."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/pages | "503-509"xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/title | "A role for muscle LIM protein (MLP) in vascular remodeling."xsd:string |
| http://purl.uniprot.org/citations/16519896 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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