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| http://purl.uniprot.org/citations/16519961 | http://www.w3.org/2000/01/rdf-schema#comment | "Proneurotensin/neuromedin N (pro NT/NMN) is the common precursor of two biologically active peptides, neurotensin (NT) and neuromedin N (NMN). We have established antibodies against peptide sequences of the NT/NMN precursor and developed a sandwich immunoassay for the detection of pro NT/NMN immunoreactivity in human circulation. Endogenous pro NT/NMN immunoreactivity was enriched by affinity chromatography using antibodies against two different pro NT/NMN epitopes, and further purified by reversed phase HPLC. Mass spectrometry analysis revealed pro NT/NMN 1-117 as major pro NT/NMN immunoreactivity in human circulation. Pro NT/NMN 1-117 is detectable in serum from healthy individuals (n = 124; median 338.9 pmol/L). As known for NT, the release of pro NT/NMN 1-117 from the intestine into the circulation is stimulated by ingestion of an ordinary meal. Investigation of the pro NT/NMN 1-117 in vitro stability in human serum and plasma revealed that this molecule is stable for at least 48 h at room temperature. Since pro NT/NMN 1-117 is theoretically produced during precursor processing in stoichiometric amounts relative to NT and NMN, it could be a surrogate marker for the release of these bioactive peptides."xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2006.01.021"xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/author | "Ernst A."xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/author | "Bergmann A."xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/author | "Hellmich S."xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/pages | "1787-1793"xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/title | "Proneurotensin 1-117, a stable neurotensin precursor fragment identified in human circulation."xsd:string |
| http://purl.uniprot.org/citations/16519961 | http://purl.uniprot.org/core/volume | "27"xsd:string |
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