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http://purl.uniprot.org/citations/1652050http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1652050http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/1652050http://www.w3.org/2000/01/rdf-schema#comment"We describe the nucleic acid sequence encoding a human 5-hydroxytryptamine1D (5-HT1D) serotonin receptor and some of the functional characteristics of the gene product. The receptor gene was isolated by hybridization to a probe based on a canine thyroid cDNA (called RDC4) previously isolated by others and believed to encode a heretofore undetermined member of the guanine nucleotide-binding protein (G protein)-linked receptor family. The human clone we isolated, called MA6A, contains an apparently intronless open reading frame encoding a 377-amino acid polypeptide with the seven hydrophobic domains characteristic of G protein-linked receptors. The MA6A deduced amino acid sequence is 88% identical to that for RDC4 and 43% identical to that for the human 5-HT1A receptor. Expression of the human gene product in transfected cell lines results in the appearance of saturable high affinity 5-HT1D-type [3H]5-HT binding. The expressed receptor exhibits features indicative of coupling to Gi proteins, i.e., robust inhibition of forskolin-stimulated cAMP accumulation and formation of a pertussis toxin-sensitive high agonist affinity binding state. These findings may help clarify several ambiguities in the classification and action of serotonin receptor subtypes."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/author"Hamblin M.W."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/author"Hamblin M.W."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/author"Metcalf M.A."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/author"Metcalf M.A."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/date"1991"xsd:gYear
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/name"Mol. Pharmacol."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/name"Mol. Pharmacol."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/pages"143-148"xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/pages"143-148"xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/title"Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/title"Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor."xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/volume"40"xsd:string
http://purl.uniprot.org/citations/1652050http://purl.uniprot.org/core/volume"40"xsd:string
http://purl.uniprot.org/citations/1652050http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1652050
http://purl.uniprot.org/citations/1652050http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/1652050
http://purl.uniprot.org/citations/1652050http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1652050
http://purl.uniprot.org/citations/1652050http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/1652050
http://purl.uniprot.org/uniprot/P28221http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/1652050
http://purl.uniprot.org/uniprot/P28221#attribution-2747933EF6E2CEB6FB18EC05BE9D0F0Ahttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1652050
http://purl.uniprot.org/uniprot/P28221#attribution-2E342E8EAFEE3C650A5116051B918A61http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1652050
http://purl.uniprot.org/uniprot/P28221#attribution-BC572E931EEFFED48D65131536AFFDFEhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/1652050