| http://purl.uniprot.org/citations/16522806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16522806 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16522806 | http://www.w3.org/2000/01/rdf-schema#comment | "The human protein PTD012 is the longer product of an alternatively spliced gene and was described to be localized in the nucleus. The X-ray structure analysis at 1.7 A resolution of PTD012 through SAD phasing reveals a monomeric protein and a novel fold. The shorter splice form was also studied and appears to be unfolded and non-functional. The structure of PTD012 displays an alphabetabetaalpha four-layer topology. A metal ion residing between the central beta-sheets is partially coordinated by three histidine residues. X-ray absorption near-edge structure (XANES) analysis identifies the PTD012-bound ion as Zn(2+). Tetrahedral coordination of the ion is completed by the carboxylate oxygen atom of an acetate molecule taken up from the crystallization buffer. The binding of Zn(2+) to PTD012 is reminiscent of zinc-containing enzymes such as carboxypeptidase, carbonic anhydrase, and beta-lactamase. Biochemical assays failed to demonstrate any of these enzyme activities in PTD012. However, PTD012 exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.052037006"xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.org/dc/terms/identifier | "doi:10.1110/ps.052037006"xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Goetz F."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Goetz F."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Manjasetty B.A."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Manjasetty B.A."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Gobom J."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Gobom J."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Heinemann U."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Heinemann U."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Buessow K."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Buessow K."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Roske Y."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Roske Y."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Scheich C."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Scheich C."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Niesen F.H."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Niesen F.H."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Fieber-Erdmann M."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/author | "Fieber-Erdmann M."xsd:string |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16522806 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |