| http://purl.uniprot.org/citations/1652368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1652368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1652368 | http://www.w3.org/2000/01/rdf-schema#comment | "A unique mRNA produced in leukemic cells from a t(15;17) acute promyelocytic leukemia (APL) patient encodes a fusion protein between the retinoic acid receptor alpha (RAR alpha) and a myeloid gene product called PML. PML contains a cysteine-rich region present in a new family of apparent DNA-binding proteins that includes a regulator of the interleukin-2 receptor gene (Rpt-1) and the recombination-activating gene product (RAG-1). Accordingly, PML may represent a novel transcription factor or recombinase. The aberrant PML-RAR fusion product, while typically retinoic acid responsive, displays both cell type- and promoter-specific differences from the wild-type RAR alpha. Because patients with APL can be induced into remission with high dose RA therapy, we propose that the nonliganded PML-RAR protein is a new class of dominant negative oncogene product. Treatment with RA would not only relieve this inhibition, but the activated PML-RAR protein may actually promote myelocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(91)90112-c"xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(91)90112-c"xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(91)90112-C"xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Kakizuka A."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Kakizuka A."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Dmitrovsky E."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Dmitrovsky E."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Murty V.V."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Murty V.V."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Miller W.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Miller W.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Frankel S.R."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Frankel S.R."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Umenono K."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Umenono K."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Warrell R.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/author | "Warrell R.P. Jr."xsd:string |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1652368 | http://purl.uniprot.org/core/name | "Cell"xsd:string |