| http://purl.uniprot.org/citations/16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16525016 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat-shock protein of 47 kDa (Hsp47) is a molecular chaperone that recognizes collagen triple helices in the endoplasmic reticulum (ER). Hsp47-knockout mouse embryos are deficient in the maturation of collagen types I and IV, and collagen triple helices formed in the absence of Hsp47 show increased susceptibility to protease digestion. We show here that the fibrils of type I collagen produced by Hsp47-/-cells are abnormally thin and frequently branched. Type I collagen was highly accumulated in the ER of Hsp47-/-cells, and its secretion rate was much slower than that of Hsp47+/+ cells, leading to accumulation of the insoluble aggregate of type I collagen within the cells. Transient expression of Hsp47 in the Hsp47-/-cells restored normal extracellular fibril formation and intracellular localization of type I collagen. Intriguingly, type I collagen with unprocessed N-terminal propeptide (N-propeptide) was secreted from Hsp47-/-cells and accumulated in the extracellular matrix. These results indicate that Hsp47 is required for correct folding and prevention of aggregation of type I collagen in the ER and that this function is indispensable for efficient secretion, processing, and fibril formation of collagen."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e05-11-1065"xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Ishida Y."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Nagata K."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Yamamoto A."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Kitamura A."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Kubota H."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/author | "Bachinger H.P."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/pages | "2346-2355"xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/title | "Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis."xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/16525016 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16525016 |
| http://purl.uniprot.org/citations/16525016 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16525016 |
| http://purl.uniprot.org/uniprot/#_A0A140LHD6-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_A0A140LHK0-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_A0A140LHR4-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_P19324-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_Q3TJK3-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_Q3TWG9-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_Q3TMD2-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_Q8BVU9-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |
| http://purl.uniprot.org/uniprot/#_Q8BV87-mappedCitation-16525016 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16525016 |