| http://purl.uniprot.org/citations/16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16527988 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we have demonstrated that STAT-3 plays a role in thrombin-induced VSMC motility. To learn more about the role of STATs in the mitogenic and chemotactic signaling events of thrombin, here we have studied the role of STAT-5. Thrombin activated STAT-5 as measured by its tyrosine phosphorylation, DNA binding, and reporter gene activity. Inhibition of STAT-5B, but not STAT-5A, by adenovirus-mediated expression of its respective dominant-negative mutants suppressed thrombin-induced VSMC growth and motility. Thrombin induced the expression of Hsp27 and FGF-2 in a time- and STAT-5B-dependent manner in VSMC. In addition, small interfering RNA-directed depletion of Hsp27 levels or adenovirus-mediated expression of its dominant-negative mutant attenuated thrombin-induced FGF-2 expression, growth, and motility of VSMC. An increased association of STAT-5B with STAT-3 occurred in response to thrombin and adenovirus-mediated expression of dnSTAT-3 suppressed thrombin-induced Hsp27 and FGF-2 induction, DNA synthesis and motility in VSMC. Together, these results indicate that thrombin-induced VSMC growth and motility require STAT-5B/STAT-3-dependent expression of Hsp27 and FGF-2. These observations also suggest that STAT-5B/STAT-3/Hsp27/FGF-2 signaling via its involvement in the regulation of VSMC growth and motility may play an important role in the pathogenesis of vascular diseases such as restenosis after angioplasty."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.res.0000216954.55724.a2"xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Cao H."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Srivastava K."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Rao G.N."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Gerthoffer W.T."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Rizvi F."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/author | "Dronadula N."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/pages | "913-922"xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/title | "Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility."xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/16527988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16527988 |
| http://purl.uniprot.org/citations/16527988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16527988 |
| http://purl.uniprot.org/uniprot/P52632#attribution-1B05102FAA322930BA7843C2FE20C1A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/P52632#attribution-B2EC5190516B402E71E21D3E2C435007 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/P52631#attribution-B2EC5190516B402E71E21D3E2C435007 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JXI4-mappedCitation-16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/#_P52631-mappedCitation-16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/#_P52632-mappedCitation-16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JSR4-mappedCitation-16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16527988 |
| http://purl.uniprot.org/uniprot/#_A6J0A2-mappedCitation-16527988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16527988 |