| http://purl.uniprot.org/citations/16531609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16531609 | http://www.w3.org/2000/01/rdf-schema#comment | "The copper chaperone for superoxide dismutase (CCS) is an intracellular metallochaperone required for incorporation of copper into the essential antioxidant enzyme copper/zinc superoxide dismutase (SOD1). Nutritional studies have revealed that the abundance of CCS is inversely proportional to the dietary and tissue copper content. To determine the mechanisms of copper-dependent regulation of CCS, copper incorporation into SOD1 and SOD1 enzymatic activity as well as CCS abundance and half-life were determined after metabolic labeling of CCS-/-fibroblasts transfected with wild-type or mutant CCS. Wild-type CCS restored SOD1 activity in CCS-/-fibroblasts, and the abundance of this chaperone in these cells was inversely proportional to the copper content of the media, indicating that copper-dependent regulation of CCS is entirely post-translational. Although mutational studies demonstrated no role for CCS Domain I in this copper-dependent regulation, similar analysis of the CXC motif in Domain III revealed a critical role for these cysteine residues in mediating copper-dependent turnover of CCS. Further mutational studies revealed that this CXC-dependent copper-mediated turnover of CCS is independent of the mechanisms of delivery of copper to SOD1 including CCS-SOD1 interaction. Taken together these data demonstrate a mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1, revealing a unique post-translational component of intracellular copper homeostasis."xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m601580200"xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/author | "Bartnikas T.B."xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/author | "Gitlin J.D."xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/author | "Caruano-Yzermans A.L."xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/pages | "13581-13587"xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/title | "Mechanisms of the copper-dependent turnover of the copper chaperone for superoxide dismutase."xsd:string |
| http://purl.uniprot.org/citations/16531609 | http://purl.uniprot.org/core/volume | "281"xsd:string |
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