| http://purl.uniprot.org/citations/16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16532032 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in Wnt pathway genes are rare in human breast cancer, yet activation of the pathway is evident from the misolocalization of beta-catenin. We searched for relationships in the expression of Wnt pathway genes and found that both secreted frizzled related protein 1 (Sfrp1) and TCF-4 transcripts were all highly downregulated in a common subset of breast cancers relative to normal breast tissue. Sfrp1 has been previously characterized as a Wnt inhibitor, and we found that interfering with its expression in the human mammary epithelial cell line MCF10A activated Wnt signaling. Reduction of TCF-4 levels in breast cancer was surprising as it is a transcription factor that is responsive to Wnt signaling. Therefore, we investigated a possible inhibitory role for TCF-4 in human breast cells as well as further characterizing Sfrp1. We identified CD24 as a Wnt target in MCF10A cells and used its expression a marker of Wnt signaling. Interfering with either Sfrp1 or TCF-4 in this cell line enhanced CD24 expression. Furthermore, removal of TCF/LEF binding sites in a CD24-luciferase reporter resulted in elevated reporter gene expression. Our results indicate that both Sfrp1 and TCF-4 repress Wnt signaling in breast tissue and their downregulation contributes to the activation of Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209470"xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Sakanaka C."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Polakis P."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Koeppen H."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Shulewitz M."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/author | "Soloviev I."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/pages | "4361-4369"xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/title | "Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer."xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16532032 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16532032 |
| http://purl.uniprot.org/citations/16532032 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16532032 |
| http://purl.uniprot.org/uniprot/P25063#attribution-5DB2254B720205660CA8D180C4945CF8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/P25063#attribution-C3D14B891017A6F8E767FAF3EE6E11AB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/Q9NQB0#attribution-5ABEA4FC242D89927DDBD88C9BAE2ABA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/Q9NQB0#attribution-5DB2254B720205660CA8D180C4945CF8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/#_E2GH26-mappedCitation-16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16532032 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-16532032 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16532032 |