| http://purl.uniprot.org/citations/16537370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16537370 | http://www.w3.org/2000/01/rdf-schema#comment | "Most class I MHC ligands are generated from the vast majority of cellular proteins by proteolysis within the ubiquitin-proteasome pathway and are presented on the cell surface by MHC class I molecules. Here, we present the crystallographic analysis of yeast 20S proteasome in complex with the inhibitor homobelactosin C. The structure reveals a unique inhibitor-binding mode and provides information about the composition of proteasomal primed substrate-binding sites. IFN-gamma inducible substitution of proteasomal constitutive subunits by immunosubunits modulates characteristics of generated peptides, thus producing fragments with higher preference for binding to MHC class I molecules. The structural data for the proteasome:homobelactosin C complex provide an explanation for involvement of immunosubunits in antigen generation and open perspectives for rational design of ligands, inhibiting exclusively constitutive proteasomes or immunoproteasomes."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0600647103"xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/author | "Groll M."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/author | "Huber R."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/author | "Larionov O.V."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/author | "de Meijere A."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/pages | "4576-4579"xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/title | "Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation."xsd:string |
| http://purl.uniprot.org/citations/16537370 | http://purl.uniprot.org/core/volume | "103"xsd:string |
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