| http://purl.uniprot.org/citations/16537382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16537382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16537382 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises >1% of total brain protein but is almost absent from other tissues [Wilkinson, K. D., et al. (1989) Science 246, 670-673]. Mutations in the UCH-L1 gene have been reported to be linked to susceptibility to and protection from Parkinson's disease [Leroy, E., et al. (1998) Nature 395, 451-452; Maraganore, D. M., et al. (1999) Neurology 53, 1858-1860]. Abnormal overexpression of UCH-L1 has been shown to correlate with several forms of cancer [Hibi, K., et al. (1998) Cancer Res. 58, 5690-5694]. Because the amino acid sequence of UCH-L1 is similar to that of other ubiquitin C-terminal hydrolases, including the ubiquitously expressed UCH-L3, which appear to be unconnected to neurodegenerative disease, the structure of UCH-L1 and the effects of disease associated mutations on the structure and function are of considerable importance. We have determined the three-dimensional structure of human UCH-L1 at 2.4-A resolution by x-ray crystallography. The overall fold resembles that of other ubiquitin hydrolases, including UCH-L3, but there are a number of significant differences. In particular, the geometry of the catalytic residues in the active site of UCH-L1 is distorted in such a way that the hydrolytic activity would appear to be impossible without substrate induced conformational rearrangements."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0510403103"xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0510403103"xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Petsko G.A."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Petsko G.A."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Ringe D."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Ringe D."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Hoang Q.Q."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Hoang Q.Q."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Ray S.S."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Ray S.S."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Das C."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Das C."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Luchansky S.J."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Luchansky S.J."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Kreinbring C.A."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Kreinbring C.A."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Lansbury P.T."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Lansbury P.T."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Meray R.K."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/author | "Meray R.K."xsd:string |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16537382 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |