| http://purl.uniprot.org/citations/16537810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16537810 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) are able to interact with pathogen-derived products and their signals induce the coordinated activation of innate and adaptive immune mechanisms. Dendritic cells (DCs) play a central role in these events. As the different TLRs are able to trigger MyD88/TRIF-dependent and -independent signaling pathways, we wondered if the simultaneous activation of these signaling cascades would synergize with respect to DC activation and induce superior cytotoxic T-lymphocyte (CTL) activity in vivo. We observed that indeed the combined activation of MyD88-dependent and -independent signaling induced by TLR7 and TLR3 ligands provoked a more rapid and more sustained bone marrow-derived DC (BMDC) activation with regard to the secretion of proinflammatory cytokines, like IL-6 and IL-12p70, and the expression of costimulatory molecules like CD40, CD70, and CD86. Furthermore, in the presence of combined TLR ligand-stimulated DCs, CD4(+) and CD8(+) T cells were insensitive toward the inhibitory effects of regulatory T cells. Most importantly, peptide-loaded BMDCs stimulated by TLR ligand combinations resulted in a marked increase of CTL effector functions in wild-type mice in vivo. Thus, our results provide evidence that unlocking the full potential of DCs by advanced activation protocols will boost their immunogenic potential and improve DC-based vaccination strategies."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-10-4015"xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Schmitt E."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Schmid B."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Schild H."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Warger T."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Heib V."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Radsak M.P."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Osterloh P."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Rechtsteiner G."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/author | "Fassbender M."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/pages | "544-550"xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/title | "Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo."xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/16537810 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16537810 |
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| http://purl.uniprot.org/uniprot/#_A2AHJ1-mappedCitation-16537810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16537810 |
| http://purl.uniprot.org/uniprot/#_A2AHJ2-mappedCitation-16537810 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16537810 |