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| http://purl.uniprot.org/citations/16540102 | http://www.w3.org/2000/01/rdf-schema#comment | "The acrosome is a secretory vesicle attached to the nucleus of the sperm. Our hypothesis is that microtubules participate in the membrane traffic between the Golgi apparatus and acrosome during the first steps of spermatid differentiation. In this work, we show that nocodazole-induced microtubule depolarization triggers the formation of vesicles of the acrosomal membrane, without detaching the acrosome from the nuclear envelope. Nocodazole also induced fragmentation of the Golgi apparatus as determined by antibodies against giantin, golgin-97 and GM130, and electron microscopy. Conversely, neither the acrosome nor the Golgi apparatus underwent fragmentation in elongating spermatids (acrosome- and maturation-phase). The microtubule network of round spermatids of azh/azh mice also became disorganized. Disorganization correlated with fragmentation of the acrosome and the Golgi apparatus, as evaluated by domain-specific markers. Elongating spermatids (acrosome and maturation-phase) of azh/azh mice also had alterations in microtubule organization, acrosome, and Golgi apparatus. Finally, the spermatozoa of azh/azh mice displayed aberrant localization of the acrosomal protein sp56 in both the post-acrosomal and flagellum domains. Our results suggest that microtubules participate in the formation and/or maintenance of the structure of the acrosome and the Golgi apparatus and that the organization of the microtubules in round spermatids is key to sorting acrosomal proteins to the proper organelle."xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2006.02.001"xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/author | "Moreno R.D."xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/author | "Schatten G."xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/author | "Palomino J."xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/pages | "218-227"xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/title | "Assembly of spermatid acrosome depends on microtubule organization during mammalian spermiogenesis."xsd:string |
| http://purl.uniprot.org/citations/16540102 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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