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http://purl.uniprot.org/citations/16540317http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16540317http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16540317http://www.w3.org/2000/01/rdf-schema#comment"Human methionine aminopeptidase type 2 (hMetAP-2) was identified as the molecular target of anti-angiogenic agents such as fumagillin and its analogues. We describe here the crystal structure of hMetAP-2 in complex with l-methionine and d-methionine at 1.9 and 2.0A resolution, respectively. The comparison of the structure of the two complexes establishes the basis of enantiomer discrimination and provides some considerations for the design of selective MetAP-2 inhibitors."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2006.02.047"xsd:string
http://purl.uniprot.org/citations/16540317http://purl.org/dc/terms/identifier"doi:10.1016/j.bmcl.2006.02.047"xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Clardy J."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Clardy J."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Nonato M.C."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Nonato M.C."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Widom J."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/author"Widom J."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/name"Bioorg. Med. Chem. Lett."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/name"Bioorg. Med. Chem. Lett."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/pages"2580-2583"xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/pages"2580-2583"xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/title"Human methionine aminopeptidase type 2 in complex with L- and D-methionine."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/title"Human methionine aminopeptidase type 2 in complex with L- and D-methionine."xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/16540317http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/16540317http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16540317
http://purl.uniprot.org/citations/16540317http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16540317
http://purl.uniprot.org/citations/16540317http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16540317
http://purl.uniprot.org/citations/16540317http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16540317