| http://purl.uniprot.org/citations/16540644 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16540644 | http://www.w3.org/2000/01/rdf-schema#comment | "UV-induced DNA damage is the basis for the development of UV-mediated skin cancer because reduction of DNA damage lowers the risk for photocarcinogenesis. The cytokine interleukin (IL)-12 was shown to exhibit the capacity to reduce UV-induced DNA damage presumably via induction of nucleotide excision repair. Because IL-12 is also produced in the skin, we wondered whether endogenous IL-12 protects from photocarcinogenesis. Therefore, we used knockout mice that lack the IL-12p40 chain and thus do not secrete biologically active IL-12. IL-12p40 knockout (IL-12p40-/-) and wild-type (wt) mice were exposed thrice weekly to UV. Skin biopsies obtained after 6 weeks revealed significantly increased numbers of sunburn cells in IL-12p40-/-mice. Additionally, a higher load of UV-induced pyrimidine dimers could be detected in the skin of UV-exposed IL-12p40-/-mice. Staining of epidermal sheets with an antibody against the tumor suppressor gene p53 revealed a higher number of p53 patches in the skin of IL-12p40-/-mice. After approximately 200 days, first skin tumors developed. Kaplan-Meier analysis indicated a significantly increased probability of tumor development in the IL-12p40-/-mice. In addition, the number of tumors developing in the individual mice was significantly higher in IL-12p40-/-mice than in wt mice. Tumors obtained in IL-12p40-/-mice grew faster than those obtained from wt mice on inoculation into nu/nu mice. This was confirmed in an electrophysiologic assay evaluating the intrinsic invasive potency of tumor cells. Together, these data indicate that IL-12 deficiency is associated with an increased risk to develop UV-induced skin cancer, implying that endogenous IL-12 may protect from photocarcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-3614"xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Maeda A."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Schwarz A."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Schwarz T."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Schneider S.W."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/author | "Beissert S."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/pages | "2962-2969"xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/title | "Enhanced photocarcinogenesis in interleukin-12-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/16540644 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16540644 |
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