| http://purl.uniprot.org/citations/16540691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16540691 | http://www.w3.org/2000/01/rdf-schema#comment | "The Prp19-associated complex, consisting of at least eight protein components, is involved in spliceosome activation by specifying the interaction of U5 and U6 with pre-mRNA for their stable association with the spliceosome after U4 dissociation. We show here that yeast cells depleted of one or two of the Prp19-associated components, accumulate the free form of U4. In NTC25-deleted cells, the level of U6 was also reduced. Extracts prepared from NTC25-deleted cells contained neither free U4 nor U6 and were ineffective in spliceosome recycling in the in vitro splicing reaction. Overexpression of U6 partially rescued the temperature-sensitive growth defect and decreased the relative amount of free U4 in NTC25-deleted cells, indicating that the accumulation of free U4 was a consequence of insufficient amounts of U6 snRNA. Extracts prepared from U6-overproducing NTC25-deleted cells containing free-form U6 were capable of spliceosome recycling, suggesting a role of free U6 RNP in spliceosome recycling. Our results demonstrate that in addition to direct participation in spliceosome activation, the Prp19-associated complex has an indirect role in spliceosome recycling through affecting the biogenesis of U4/U6 snRNP in the in vivo splicing reaction."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.2292106"xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Lin J.Y."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Kao T.C."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Chan S.P."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Cheng S.C."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/author | "Kao D.I."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/name | "RNA"xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/pages | "765-774"xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/title | "Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling."xsd:string |
| http://purl.uniprot.org/citations/16540691 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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