| http://purl.uniprot.org/citations/16542392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16542392 | http://www.w3.org/2000/01/rdf-schema#comment | "It is assumed that the combined effects of multiple common genetic variants explain a large part of variation of high-density lipoprotein cholesterol (HDL-C) plasma levels, but little evidence exists to corroborate this assumption. It was our objective to study the contribution of multiple common genetic variants of HDL-C-related genes to variation of HDL-C plasma levels. A well-characterized cohort of 546 Caucasian men with documented coronary artery disease was genotyped for common functional variants in genes that control reverse cholesterol transport: ATP-binding cassette transporter A1, apolipoprotein A-I and apolipoprotein-E, cholesteryl ester transfer protein, hepatic lipase, lecithin : cholesterol-acyl transferase, lipoprotein lipase, and scavenger receptor class B type 1. Multivariate linear regression showed that these variants, in conjunction, explain 12.4% (95% confidence interval: 6.9-17.9%) of variation in HDL-C plasma levels. When the covariates smoking and body mass index were taken into account, the explained variation increased to 15.3% (9.4-21.2%), and when 10 two-way interactions were incorporated, this percentage rose to 25.2% (18.9-31.5%). This study supports the hypothesis that multiple, mildly penetrant, but highly prevalent genetic variants explain part of the variation of HDL-C plasma levels, albeit to a very modest extent. Multiple environmental and genetic influences on HDL-C plasma levels still have to be elucidated."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1399-0004.2006.00578.x"xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Hovingh G.K."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Jukema J.W."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Zwinderman A.H."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Kastelein J.J."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Reitsma P.H."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Boekholdt S.M."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Tanck M.W."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Kuivenhoven J.A."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Jansen H."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Doevendans P.A."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "van der Wall E.E."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Schiffers P.M."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Souverein O.W."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/author | "Peters R.I."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/name | "Clin Genet"xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/pages | "263-270"xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/title | "Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels."xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/16542392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16542392 |
| http://purl.uniprot.org/citations/16542392 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16542392 |
| http://purl.uniprot.org/uniprot/#_A0A024R3E3-mappedCitation-16542392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16542392 |