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http://purl.uniprot.org/citations/16545789http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16545789http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16545789http://www.w3.org/2000/01/rdf-schema#comment"

Background

C6orf37 was a gene up-regulated in colorectal adenoma in our previous study. A variable region of C6orf37 sequence was found when we blasted its full sequence with NCBI nucleotide database.

Methods

RT-PCR and sequencing were conducted to identify the variable region of C6orf37 as VNTR. DHPLC was applied to detect the VNTR genotypes in 122 colorectal carcinoma patients and 166 healthy controls.

Results

A novel VNTR sequence found in C6orf37 second exon was composed of 15 base pair consensus sequence encoding 5-amino-acid (G-G-D-F-G). The repeat timePOST alleles contain three repeats (a), 4 repeats (b) and 5 repeats (c), respectively, which produced 3 homozygotes (a/a, b/b and c/c) and 3 heterozygotes (a/b, a/c and b/c). a, b, c allele frequencies were 0.145, 0.304, 0.551, respectively in Chinese population. Heterozygosity (H) was 0.583. Polymorphism information content (PIC) was 0.510. The distribution of genotypes and allele frequencies of the VNTR reached no significant difference between patients and healthy controls and there was no correlation between VNTR polymorphism and colorectal cancer clincopathological features.

Conclusion

A novel VNTR polymorphism in C6orf37 exists in Chinese population and is not associated with colorectal cancer risk."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.org/dc/terms/identifier"doi:10.1016/j.cca.2005.12.043"xsd:string
http://purl.uniprot.org/citations/16545789http://purl.org/dc/terms/identifier"doi:10.1016/j.cca.2005.12.043"xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lin J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lin J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Ma Y."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Ma Y."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Wang W."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Cui J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Cui J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Yao C."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Yao C."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lai M.D."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lai M.D."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lv B.J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Lv B.J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Ruan W.J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Ruan W.J."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Xu E.P."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/author"Xu E.P."xsd:string
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16545789http://purl.uniprot.org/core/date"2006"xsd:gYear
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