| http://purl.uniprot.org/citations/16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16547175 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila, dosage compensation is achieved by a twofold up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. How the MSL complex is targeted to X-linked genes and whether its recruitment at a local level is necessary and sufficient to ensure dosage compensation remain poorly understood. Here we report the MSL-1-binding profile along the male X chromosome in embryos and male salivary glands isolated from third instar larvae using chromatin immunoprecipitation (ChIP) coupled with DNA microarray (ChIP-chip). This analysis has revealed that majority of the MSL-1 targets are primarily expressed during early embryogenesis and many target genes possess DNA replication element factor (DREF)-binding sites in their promoters. In addition, we show that MSL-1 distribution remains stable across development and that binding of MSL-1 on X-chromosomal genes does not correlate with transcription in male salivary glands. These results show that transcription per se on the X chromosome cannot be the sole signal for MSL-1 recruitment. Furthermore, genome-wide analysis of the dosage-compensated status of X-linked genes in male and female shows that most of the X chromosome remains compensated without direct MSL-1 binding near the gene. Our results, therefore, provide a comprehensive overview of MSL-1 binding and dosage-compensated status of X-linked genes and suggest a more global effect of MSL complex on X-chromosome regulation."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.377506"xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/author | "Lercher M.J."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/author | "Akhtar A."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/author | "Legube G."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/author | "McWeeney S.K."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/pages | "871-883"xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/title | "X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16547175 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16547175 |
| http://purl.uniprot.org/citations/16547175 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16547175 |
| http://purl.uniprot.org/uniprot/#_A0A023GPN7-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A0A023GPV6-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A0A0S0X7Z4-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_P54352-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V3W1-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V3W2-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V438-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V4A1-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V4I0-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A4V4N7-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |
| http://purl.uniprot.org/uniprot/#_A0A6H2EEH5-mappedCitation-16547175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547175 |