| http://purl.uniprot.org/citations/16547242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16547242 | http://www.w3.org/2000/01/rdf-schema#comment | "The EphA receptor tyrosine kinases interact with membrane-bound ligands of the ephrin-A subfamily. Interaction induces EphA receptor oligomerization, tyrosine phosphorylation, and, as a result, EphA receptor signaling. EphA receptors have been shown to regulate cell survival, migration, and cell-cell and cell-matrix interactions. However, their functions in lymphoid cells are only beginning to be described. We show in this study that functional EphA receptors are expressed by murine thymocytes, including CD4(+)CD8(+), CD4(+)CD8(-), and CD4(-)CD8(+) subpopulations. We demonstrate that activation of EphA receptors by the ephrin-A1 ligand inhibits the anti-CD3-induced apoptosis of CD4(+)CD8(+) double-positive thymocytes. Furthermore, ephrin-A1 costimulation suppresses up-regulation of both the IL-2R alpha-chain (CD25) and early activation Ag CD69 and can block IL-2 production by CD4(+) single-positive cells. In agreement, EphA receptor activation in thymocytes also inhibits TCR-induced activation of the Ras-MAPK pathway. Our findings suggest that EphA receptor activation is antithetical to TCR signaling in thymocytes, and that the level of engagement by ephrin-A proteins on thymic APCs regulates thymocyte selection."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.176.7.4066"xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/author | "Miller C.D."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/author | "Roifman C.M."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/author | "Freywald A."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/author | "Rashotte C."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/author | "Sharfe N."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/pages | "4066-4074"xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/title | "EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes."xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/16547242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16547242 |
| http://purl.uniprot.org/citations/16547242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16547242 |
| http://purl.uniprot.org/uniprot/P52793#attribution-B168C3A2C5552CECF338F10CE133ED9B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16547242 |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SUP4-mappedCitation-16547242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547242 |
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| http://purl.uniprot.org/uniprot/#_A2BDQ4-mappedCitation-16547242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547242 |