| http://purl.uniprot.org/citations/16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16547505 | http://www.w3.org/2000/01/rdf-schema#comment | "TCF-4 is the main effector of the Wnt/Wingless signalling pathway. As with other TCF/LEF factors, numerous alternative splicings at its 3' end affect its expression. Such a mechanism leads to the synthesis of numerous TCF-4 isoforms among which some contain binding domains for CtBP, an ubiquitous transcriptional corepressor. Of interest, we described a frequent TCF-4 frameshift mutation in mismatch-repair deficient colorectal cancers (MSI-H cancers) that leads to the selective loss of TCF-4 isoforms with CtBP binding abilities. We provide here data that argue for a partial colocalization of CtBP with TCF-4 isoforms containing CtBP binding domains in cellulo, and for a functional role of CtBP in repressing TCF-4 mediated transcription. We also demonstrate that such a colocalization is not observed in MSI-H colorectal cancer cells that harbour the TCF-4 frameshift mutation, and that CtBP is not able to repress TCF-4-mediated transcription in this context. Taken together, our results strongly suggest that CtBP would play a role in regulating TCF-4 mediated transcription upon its binding with some TCF-4 isoforms encoded by alternatively spliced mRNA. They also suggest a role for TCF-4 frameshift mutation during MSI-H colorectal tumour progression, by regulating the relative proportion of the different TCF-4 isoforms."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209471"xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Hamelin R."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Duval A."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Flejou J.F."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Fontanges P."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Buhard O."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Cuilliere-Dartigues P."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "El-Bchiri J."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/author | "Krimi A."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/pages | "4441-4448"xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/title | "TCF-4 isoforms absent in TCF-4 mutated MSI-H colorectal cancer cells colocalize with nuclear CtBP and repress TCF-4-mediated transcription."xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16547505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16547505 |
| http://purl.uniprot.org/citations/16547505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16547505 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SGH8-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTL7-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |
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| http://purl.uniprot.org/uniprot/#_P56545-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |
| http://purl.uniprot.org/uniprot/#_A0A994J711-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTM8-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |
| http://purl.uniprot.org/uniprot/#_A0A2Z5HTN9-mappedCitation-16547505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16547505 |