| http://purl.uniprot.org/citations/16549667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16549667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16549667 | http://www.w3.org/2000/01/rdf-schema#comment | "Group B streptococci (GBS) are pathogens of both neonates and adults, with serotype III strains in particular being associated with invasive disease and meningitis. In this study, a novel GBS surface antigen, epsilon, was found to be co-expressed with the previously reported delta antigen on an identical subset of serotype III GBS. Expression of delta/epsilon on the surface of serotype III GBS was shown to distinguish the restriction digest pattern (RDP) III-3 and multilocus sequence typing (ST)-17 lineage. epsilon-Specific antibodies were reactive with a unique, high-molecular-mass, serine-rich repeat protein (Srr-2) found exclusively in RDP III-3 strains. The gene encoding Srr-2 was located within a putative accessory secretory locus that included secY2 and secA2 homologues and had a genetic organization similar to that of the secY2/A2 locus of staphylococci. In contrast, serotype III delta/epsilon-negative strains and strains representative of serotypes Ia, Ib, Ic and II shared a common Srr-encoding gene, srr-1, and an organization of the secY2/A2 locus similar to that of previously reported serotype Ic, delta/epsilon-negative serotype III and serotype V GBS strains. Representative serotype III delta/epsilon-positive strains had LD(90) values 3-4 logs less than those of serotype III delta/epsilon-negative strains in a neonatal mouse model of infection. These results indicate that the RDP III-3/ST-17 lineage expresses Srr-2 and is highly virulent in an in vivo model of neonatal sepsis."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.28516-0"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.org/dc/terms/identifier | "doi:10.1099/mic.0.28516-0"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Crowley P.J."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Crowley P.J."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Brady L.J."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Brady L.J."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Adderson E.E."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Adderson E.E."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Bohnsack J.F."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Bohnsack J.F."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Seifert K.N."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Seifert K.N."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Whiting A.A."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/author | "Whiting A.A."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/name | "Microbiology"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/pages | "1029-1040"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/pages | "1029-1040"xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/title | "A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae."xsd:string |
| http://purl.uniprot.org/citations/16549667 | http://purl.uniprot.org/core/title | "A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae."xsd:string |