| http://purl.uniprot.org/citations/16550596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16550596 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies from our laboratory and others have suggested that increased expression of cox-2 is important in the genesis of esophageal adenocarcinoma. In vitro studies suggest that cox-2 regulates expression of the anti-apoptotic protein bcl-2, thus possibly accounting for reduced apoptosis in carcinogenesis. The aim of this study was to investigate the relationship of these 2 genes in the development of Barrett's-associated adenocarcinoma. Histologic sections from endoscopic biopsies or esophagectomy specimens were classified as non-dysplastic Barrett's (n = 30), intraepithelial neoplasia (n = 12) and adenocarcinoma (n = 48). The desired tissue was isolated by laser capture microdissection and expression levels of cox-2 and bcl-2 were measured by quantitative real-time PCR (Taqman). Gene expression levels were compared to samples of the distal esophageal squamous epithelium (n = 55) and reflux-esophagitis (n = 25), without Barrett's or cancer. Expression of both bcl-2 and cox-2 were increased in non-dysplastic Barrett's (p = 0.0077, p = 0.0037), intraepithelial neoplasia (p = 0.0053, p = 0.0220) and adenocarcinoma (p < 0.0001, p < 0.0001) compared to squamous epithelium or reflux-esophagitis. Furthermore, there is a significant correlation between these two genes, especially in carcinoma (p < 0.0001)."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.21922"xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Schneider S."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Uchida K."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Shimada H."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Shimizu D."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Danenberg K.D."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Danenberg P.V."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Kuramochi H."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Peters J.H."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Vallbohmer D."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "DeMeester S.R."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "DeMeester T.R."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/author | "Chandrasoma P.T."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/pages | "765-770"xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/title | "Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that of Bcl-2."xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/16550596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16550596 |
| http://purl.uniprot.org/citations/16550596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16550596 |
| http://purl.uniprot.org/uniprot/#_D9MWI3-mappedCitation-16550596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16550596 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ4-mappedCitation-16550596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16550596 |
| http://purl.uniprot.org/uniprot/#_P10415-mappedCitation-16550596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16550596 |