| http://purl.uniprot.org/citations/16554040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16554040 | http://www.w3.org/2000/01/rdf-schema#comment | "Sterol regulatory element binding protein (SREBP)-1 is a membrane-bound transcription factor that regulates the expression of several genes involved in cellular fatty acid synthesis in the peripheral tissues, including liver. Although SREBP-1 is expressed in brain, little is known about its function. The aim of the present study was to clarify the characteristics of SREBP-1 mRNA expression in rat brain under various nutritional and hormonal conditions. In genetically obese (fa/fa) Zucker rats, expression of SREBP-1 mRNA was greater in liver than in hypothalamus or cerebrum compared to the lean littermates of these rats. Fasting for 45 h and refeeding for 3 h did not affect expression in brains of Wistar rats of SREBP-1 mRNA or the mRNAs of lipogenic enzymes that are targets of SREBP-1, i.e., fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC). Infusion of 2.0 mIU insulin or 3.0 microg leptin into the third cerebroventricle did not affect SREBP-1 mRNA expression in either hypothalamus or cerebrum. SREBP-1 mRNA expression in brains of transgenic mice that overexpressed leptin did not differ from that of wild-type mice. However, we observed a unique age-related alteration in SREBP-1 mRNA expression in brains of Sprague-Dawley rats. Specifically, SREBP-1 mRNA expression increased between 1 and 20 months of age, while there was no such change in the expression of FAS or ACC. This raises the possibility that increased SREBP-1 expression secondary to aging-related decline of polyunsaturated fatty acid (PUFA) might compensate for the reduction of FAS expression in brain. These findings suggest that the expression of SREBP-1 and downstream lipogenic enzymes in brain is probably not regulated by peripheral nutritional conditions or humoral factors. Aging-related changes in SREBP-1 mRNA expression may be involved in developmental changes in brain lipid metabolism."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.brainres.2006.01.081"xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Okamoto K."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Masaki T."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Kakuma T."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Sakata T."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Fukuchi S."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/author | "Yoshimatsu H."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/name | "Brain Res"xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/pages | "19-27"xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/title | "Sterol regulatory element binding protein (SREBP)-1 expression in brain is affected by age but not by hormones or metabolic changes."xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://purl.uniprot.org/core/volume | "1081"xsd:string |
| http://purl.uniprot.org/citations/16554040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16554040 |
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