| http://purl.uniprot.org/citations/16557299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16557299 | http://www.w3.org/2000/01/rdf-schema#comment | "GATA transcription factors play critical roles in restricting cell lineage differentiation during development. Here, we show that conditional inactivation of GATA-6 in VSMCs results in perinatal mortality from a spectrum of cardiovascular defects, including interrupted aortic arch and persistent truncus arteriosus. Inactivation of GATA-6 in neural crest recapitulates these abnormalities, demonstrating a cell-autonomous requirement for GATA-6 in neural crest-derived SMCs. Surprisingly, the observed defects do not result from impaired SMC differentiation but rather are associated with severely attenuated expression of semaphorin 3C, a signaling molecule critical for both neuronal and vascular patterning. Thus, the primary function of GATA-6 during cardiovascular development is to regulate morphogenetic patterning of the cardiac outflow tract and aortic arch. These findings provide new insights into the conserved functions of the GATA-4, -5, and -6 subfamily members and identify GATA-6 and GATA-6-regulated genes as candidates involved in the pathogenesis of congenital heart disease."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci27363"xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Parmacek M.S."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Lepore J.J."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/author | "Mericko P.A."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/pages | "929-939"xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/title | "GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/16557299 | http://purl.uniprot.org/core/volume | "116"xsd:string |
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