| http://purl.uniprot.org/citations/16563355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16563355 | http://www.w3.org/2000/01/rdf-schema#comment | "Anchoring functions of collagen VII depend on its ability to form homotypic fibrils and to bind to other macromolecules to form heterotypic complexes. Biosensor-based binding assays were employed to analyze the kinetics of the NC1 domain-mediated binding of collagen VII to laminin 5, collagen IV, and collagen I. We showed that collagen VII interacts with laminin 5 and collagen IV with a Kd value of 10(-9) M. In contrast, the NC1-mediated binding to collagen I was weak with a Kd value of 10(-6) M. Binding assays also showed that the NC1 domain utilizes the same region to bind to both laminin 5 and collagen IV. We postulate that the ability of the NC1 domains to bind with high affinities to laminin 5 and collagen IV facilitates stabilization of the structure of the basement membrane itself and that the NC1-collagen I interaction may be less important for stabilization of the dermal-epidermal junction."xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2006.03.034"xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/author | "Uitto J."xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/author | "Fertala A."xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/author | "Brittingham R."xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/pages | "692-699"xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/title | "High-affinity binding of the NC1 domain of collagen VII to laminin 5 and collagen IV."xsd:string |
| http://purl.uniprot.org/citations/16563355 | http://purl.uniprot.org/core/volume | "343"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q13751-mappedCitation-16563355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16563355 |
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