| http://purl.uniprot.org/citations/16563390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16563390 | http://www.w3.org/2000/01/rdf-schema#comment | "In the present study, we have explored the impact of deleting a single allele of PDK1 in T cell progenitors on alpha/beta and gamma/delta T cell development. The data show that deleting a single allele of PDK1 allows differentiation of alpha/beta T cells but prevents their proliferative expansion in the thymus. Accordingly, mice with T cells that are haplo-insufficient for PDK1 have reduced numbers of thymocytes and alpha/beta peripheral T cells. T cell progenitors also give rise to gamma/delta T cells but in contrast to the loss of alpha/beta T cells in T-PDK1 null and haplo-insufficient mice, there were increased numbers of gamma/delta T cells. The production of alpha/beta T cells is dependent on the proliferative expansion of thymocytes and is determined by a balance between the frequency with which cells enter the proliferative phase of the cell cycle and rates of cell death. Herein, we show that PDK1 haplo-insufficient thymocytes have no defects in their ability to enter the cell cycle but show increased apoptosis. PDK1 thus plays a determining role in the development of alpha/beta T lymphocytes but does not limit gamma/delta T cell development."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2006.03.022"xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/author | "Kelly A.P."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/author | "Cantrell D.A."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/author | "Hinton H.J."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/author | "Clarke R.G."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/pages | "2135-2140"xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/title | "Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/16563390 | http://purl.uniprot.org/core/volume | "580"xsd:string |
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