| http://purl.uniprot.org/citations/16564010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16564010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16564010 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomere capping is the essential function of telomeres. To identify new genes involved in telomere capping, we carried out a genome-wide screen in Saccharomyces cerevisiae for suppressors of cdc13-1, an allele of the telomere-capping protein Cdc13. We report the identification of five novel suppressors, including the previously uncharacterized gene YML036W, which we name CGI121. Cgi121 is part of a conserved protein complex -- the KEOPS complex --containing the protein kinase Bud32, the putative peptidase Kae1, and the uncharacterized protein Gon7. Deletion of CGI121 suppresses cdc13-1 via the dramatic reduction in ssDNA levels that accumulate in cdc13-1 cgi121 mutants. Deletion of BUD32 or other KEOPS components leads to short telomeres and a failure to add telomeres de novo to DNA double-strand breaks. Our results therefore indicate that the KEOPS complex promotes both telomere uncapping and telomere elongation."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.12.044"xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.12.044"xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Downey M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Downey M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Durocher D."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Durocher D."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Krogan N.J."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Emili A."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Emili A."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Greenblatt J.F."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Greenblatt J.F."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Harrington L."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Harrington L."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Partington M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Partington M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Brehme M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Brehme M."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Galicia S."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Galicia S."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Guillard S."xsd:string |
| http://purl.uniprot.org/citations/16564010 | http://purl.uniprot.org/core/author | "Guillard S."xsd:string |