| http://purl.uniprot.org/citations/16565090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16565090 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16565090 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transduction within the canonical Wnt/beta-catenin pathway drives development and carcinogenesis through programmed or unprogrammed changes in gene transcription. Although the upstream events linked to signal-induced activation of beta-catenin in the cytoplasm have been deciphered in considerable detail, much less is known regarding the mechanism by which beta-catenin stimulates target gene transcription in the nucleus. Here, we show that beta-catenin physically and functionally targets the MED12 subunit in Mediator to activate transcription. The beta-catenin transactivation domain bound directly to isolated MED12 and intact Mediator both in vitro and in vivo, and Mediator was recruited to Wnt-responsive genes in a beta-catenin-dependent manner. Disruption of the beta-catenin/MED12 interaction through dominant-negative interference- or RNA interference-mediated MED12 suppression inhibited beta-catenin transactivation in response to Wnt signaling. This study thus identifies the MED12 interface within Mediator as a new component and a potential therapeutic target in the Wnt/beta-catenin pathway."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602696200"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m602696200"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Xu X."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Boyer T.G."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Boyer T.G."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Hecht A."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/author | "Hecht A."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/pages | "14066-14075"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/pages | "14066-14075"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/title | "Mediator is a transducer of Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/title | "Mediator is a transducer of Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16565090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16565090 |
| http://purl.uniprot.org/citations/16565090 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16565090 |