| http://purl.uniprot.org/citations/16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16565492 | http://www.w3.org/2000/01/rdf-schema#comment | "Respiratory infections, including influenza in humans, are often accompanied by a hepatitis that is usually mild and self-limiting. The mechanism of this kind of liver damage is not well understood. In the present study, we show that influenza-associated hepatitis occurs due to the formation of inflammatory foci that include apoptotic hepatocytes, antigen-specific CD8(+) T cells, and Kupffer cells. Serum aminotransaminase levels were elevated, and both the histological and serum enzyme markers of hepatitis were increased in secondary influenza infection, consistent with a primary role for antigen-specific T cells in the pathogenesis. No virus could be detected in the liver, making this a pure example of "collateral damage" of the liver. Notably, removal of the Kupffer cells prevented the hepatitis. Such hepatic collateral damage may be a general consequence of expanding CD8(+) T-cell populations during many extrahepatic viral infections, yielding important implications for liver pathobiology."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2006.050875"xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Treanor J.J."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Wright K.O."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Topham D.J."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Pierce R.H."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Crispe I.N."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Murray D.A."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Cornejo J.C."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/author | "Polakos N.K."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/pages | "1169-1178"xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/title | "Kupffer cell-dependent hepatitis occurs during influenza infection."xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://purl.uniprot.org/core/volume | "168"xsd:string |
| http://purl.uniprot.org/citations/16565492 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16565492 |
| http://purl.uniprot.org/citations/16565492 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16565492 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_A2AQE9-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_A2AQF0-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_A2AQF1-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |
| http://purl.uniprot.org/uniprot/#_F6Z2B2-mappedCitation-16565492 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16565492 |