| http://purl.uniprot.org/citations/16566923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16566923 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16566923 | http://www.w3.org/2000/01/rdf-schema#comment | "Human granulocyte colony stimulating factor stimulated clone-1 (hGC-1, also known as GW112, OLM4, and hOlfD) is an olfactomedin-related glycoprotein of unknown function. We performed a series of biochemical studies to characterize its function. Using hGC-1 purified from baculovirus Sf9 cells we demonstrated that hGC-1 is a secreted glycoprotein containing N-linked carbohydrate chains and forms disulfide-bonded multimers. It binds to cell surfaces and to the locutions ricinus communis agglutinin I, concanavalin A and wheat germ agglutinin. Purified hGC-1 enhanced NIH3T3 and 293T/17 cell spreading and attachment, as did hGC-1-enriched culture supernatants of 293T/17 cells transfected with an hGC-1 expression vector. Coimmunoprecipitation studies demonstrated that hGC-1 interacts with cadherin in 293T/17 cells. This interaction depends on the C-terminal olfactomedin domain, but does not require the five well-conserved cysteine residues. However, cysteine residues at 83, 85, 246 and 437 are essential for secretion, and cysteine 226 is critical for hGC-1 multimer formation. Our studies demonstrated that hGC-1, an extracellular matrix glycoprotein, facilitates cell adhesion. Its potential interaction with endogenous cell surface lectins and cadherin may mediate this function."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2006.02.011"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2006.02.011"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Zhu J."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Rodgers G.P."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/author | "Rodgers G.P."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/pages | "1785-1797"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/pages | "1785-1797"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/title | "The glycoprotein hGC-1 binds to cadherin and lectins."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/title | "The glycoprotein hGC-1 binds to cadherin and lectins."xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://purl.uniprot.org/core/volume | "312"xsd:string |
| http://purl.uniprot.org/citations/16566923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16566923 |
| http://purl.uniprot.org/citations/16566923 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16566923 |