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http://purl.uniprot.org/citations/16567828http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16567828http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The overlap between genetic susceptibility to celiac disease (CD) and to type 1 diabetes is incomplete; therefore, some genetic polymorphisms may significantly modify the risk of CD in subjects with type 1 diabetes. This study aimed to investigate whether the susceptibility to CD in diabetic children is modified by positivity for HLA-DQB1*02-DQA1*05 and DQB1*0302-DQA1*03 and by alleles of single nucleotide polymorphisms within the genes encoding CTLA4, transforming growth factor (TGF)-beta, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-1, IL-2, IL-6, and IL-10.

Research design and methods

Genotypic data were compared between 130 case subjects (children with type 1 diabetes and CD diagnosed using endomysium antibodies) and 245 control subjects (children with type 1 diabetes only, optimally two per case, matched for center, age at type 1 diabetes onset, and type 1 diabetes duration). The subjects were recruited from 10 major European pediatric diabetes centers performing regular screening for CD. The polymorphisms were determined using PCR with sequence-specific primers, and the risk was assessed by building a step-up conditional logistic regression model using variables that were significantly associated with CD in the univariate analysis.

Results

The best-fitted model showed that risk of CD is increased by presence of HLA-DQB1*02-DQA1*05 (odds ratio 4.5 [95% CI 1.8-11], for homozygosity, and 2.0 [1.1-3.7], for a single dose) and also independently by TNF -308A (1.9 [1.1-3.2], for phenotypic positivity), whereas IL1-alpha -889T showed a weak negative association (0.6 [0.4-0.9]).

Conclusions

The results indicate that the risk of CD in children with type 1 diabetes is significantly modified both by the presence of HLA-DQB1*02-DQA1*05 and by a variant of another gene within the major histocompatibility complex, the TNF -308A."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.org/dc/terms/identifier"doi:10.2337/diacare.29.04.06.dc05-1923"xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Battelino T."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Lebl J."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Schober E."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Cinek O."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Sumnik Z."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Kordonouri O."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Kulich M."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Soltesz G."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Arato A."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Bratanic N."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Danne T."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/author"Roszai B."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/date"2006"xsd:gYear
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/name"Diabetes Care"xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/pages"858-863"xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/title"Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A."xsd:string
http://purl.uniprot.org/citations/16567828http://purl.uniprot.org/core/volume"29"xsd:string
http://purl.uniprot.org/citations/16567828http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16567828
http://purl.uniprot.org/citations/16567828http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16567828
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-16567828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16567828
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-16567828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16567828
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-16567828http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16567828
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