| http://purl.uniprot.org/citations/16569662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16569662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16569662 | http://www.w3.org/2000/01/rdf-schema#comment | "The espin actin-bundling proteins, which are the target of deafness mutations, are present in the parallel actin bundles of stereocilia and microvilli and appear to increase their steady-state length. Here, we report a new activity of the espins, one that depends on their enigmatic WH2 domain: the ability to assemble a large actin bundle when targeted to a specific subcellular location. This activity was observed for wild-type espins targeted to the centrosome in transfected neuronal cells and for jerker espins targeted to the nucleolus in a wide variety of transfected cells as a result of the frameshifted peptide introduced into the espin C-terminus by the jerker deafness mutation. This activity, which appears specific to espins, requires two espin F-actin-binding sites and the actin-monomer-binding activity of the espin WH2 domain, but can be mimicked by adding a WH2 domain to an unrelated actin-bundling protein, villin. Espins do not activate the Arp2/3 complex in vitro, and bundle assembly is not indicative of in-vitro nucleation activity. Our results suggest a novel way to build actin bundles at specific sites in cells."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02869"xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.02869"xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Zheng L."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Ferreira A."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Ferreira A."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Mullins R.D."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Mullins R.D."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Kelly A.E."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Kelly A.E."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Bartles J.R."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Bartles J.R."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Mugnaini E."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Mugnaini E."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Changyaleket B."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Changyaleket B."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Loomis P.A."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Loomis P.A."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Sekerkova G."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/author | "Sekerkova G."xsd:string |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16569662 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |