| http://purl.uniprot.org/citations/16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16571783 | http://www.w3.org/2000/01/rdf-schema#comment | "K(+) secretion in the kidney and distal colon is a main determinant of K(+) homeostasis. This study investigated the identity of the relevant luminal secretory K(+) ion channel in distal colon. An Ussing chamber was used to measure ion transport in the recently generated BK channel-deficient (BK(-/-)) mice. BK(-/-) mice display a significant colonic epithelial phenotype with (1) lack of Ba(2+)-sensitive resting K(+) secretion, (2) absence of K(+) secretion stimulated by luminal P2Y(2) and P2Y(4) receptors, (3) absence of luminal Ca(2+) ionophore (A23187)-stimulated K(+) secretion, (4) reduced K(+) and increased Na(+) contents in feces, and (5) an increased colonic Na(+) absorption. In contrast, resting and uridine triphosphate (UTP)-stimulated K(+) secretion was not altered in mice that were deficient for the intermediate conductance Ca(2+)-activated K(+) channel SK4. BK channels localize to the luminal membrane of crypt, and reverse transcription-PCR results confirm the expression of the BK channel alpha-subunit in isolated distal colonic crypts. It is concluded that BK channels are the responsible K(+) channels for resting and stimulated Ca(2+)-activated K(+) secretion in mouse distal colon."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2005101111"xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Arntz C."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Ruth P."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Sausbier U."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Sausbier M."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Leipziger J."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Neuhuber W."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Matos J.E."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/author | "Beranek G."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/pages | "1275-1282"xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/title | "Distal colonic K(+) secretion occurs via BK channels."xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/16571783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16571783 |
| http://purl.uniprot.org/citations/16571783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16571783 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ41-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |
| http://purl.uniprot.org/uniprot/#_A0A087WQE1-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |
| http://purl.uniprot.org/uniprot/#_A0A087WQN5-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |
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| http://purl.uniprot.org/uniprot/#_A0A087WSQ4-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP82-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |
| http://purl.uniprot.org/uniprot/#_E9Q9P4-mappedCitation-16571783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16571783 |