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| http://purl.uniprot.org/citations/16581766 | http://www.w3.org/2000/01/rdf-schema#comment | "Surfactant protein A (SP-A) is important for immune defense within the alveolus. Cyclic AMP (cAMP) stimulation of SP-A expression in lung type II cells is O(2) dependent and mediated by increased phosphorylation and binding of thyroid transcription factor 1 (TTF-1) to an upstream response element (TTF-1-binding element [TBE]). Interleukin-1 (IL-1) stimulation of SP-A expression is mediated by NF-kappaB (p65/p50) activation and increased binding to the TBE. In this study, we found that O(2) also was permissive for IL-1 induction of SP-A expression and for cAMP and IL-1 stimulation of type II cell nuclear protein binding to the TBE. Using chromatin immunoprecipitation, we observed that when type II cells were cultured in 20% O(2), cAMP and IL-1 stimulated the recruitment of TTF-1, p65, CBP, and steroid receptor coactivator 1 to the TBE region of the SP-A promoter and increased local acetylation of histone H3; these effects were prevented by hypoxia. Hypoxia markedly reduced global levels of CBP and acetylated histone H3 and increased the expression of histone deacetylases. Furthermore, hypoxia caused a global increase in histone H3 dimethylated on Lys9 and increased the association of dimethyl histone H3 with the SP-A promoter. These results, together with findings that the histone deacetylase inhibitor trichostatin A and the methyltransferase inhibitor 5'-deoxy(5'-methylthio)adenosine markedly enhanced SP-A expression in lung type II cells, suggest that increased O(2) availability to type II cells late in gestation causes epigenetic changes that permit access of TTF-1 and NF-kappaB to the SP-A promoter. The binding of these transcription factors facilitates the recruitment of coactivators, resulting in the further opening of the chromatin structure and activation of SP-A transcription."xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.8.2901-2912.2006"xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/author | "Mendelson C.R."xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/author | "Islam K.N."xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/pages | "2901-2912"xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/title | "Permissive effects of oxygen on cyclic AMP and interleukin-1 stimulation of surfactant protein A gene expression are mediated by epigenetic mechanisms."xsd:string |
| http://purl.uniprot.org/citations/16581766 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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