| http://purl.uniprot.org/citations/16581799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16581799 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutation of the nuclear receptor peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) severely affects placenta development, leading to embryonic death at embryonic day 9.5 (E9.5) to E10.5 of most, but not all, PPARbeta/delta-null mutant embryos. While very little is known at present about the pathway governed by PPARbeta/delta in the developing placenta, this paper demonstrates that the main alteration of the placenta of PPARbeta/delta-null embryos is found in the giant cell layer. PPARbeta/delta activity is in fact essential for the differentiation of the Rcho-1 cells in giant cells, as shown by the severe inhibition of differentiation once PPARbeta/delta is silenced. Conversely, exposure of Rcho-1 cells to a PPARbeta/delta agonist triggers a massive differentiation via increased expression of 3-phosphoinositide-dependent kinase 1 and integrin-linked kinase and subsequent phosphorylation of Akt. The links between PPARbeta/delta activity in giant cells and its role on Akt activity are further strengthened by the remarkable pattern of phospho-Akt expression in vivo at E9.5, specifically in the nucleus of the giant cells. In addition to this phosphatidylinositol 3-kinase/Akt main pathway, PPARbeta/delta also induced giant cell differentiation via increased expression of I-mfa, an inhibitor of Mash-2 activity. Finally, giant cell differentiation at E9.5 is accompanied by a PPARbeta/delta-dependent accumulation of lipid droplets and an increased expression of the adipose differentiation-related protein (also called adipophilin), which may participate to lipid metabolism and/or steroidogenesis. Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.26.8.3266-3281.2006"xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Trono D."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Desvergne B."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Tan N.S."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Wahli W."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Basu-Modak S."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Anghel S.I."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Joye E."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/author | "Nadra K."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/pages | "3266-3281"xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/title | "Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta."xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/16581799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16581799 |
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