| http://purl.uniprot.org/citations/16584883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16584883 | http://www.w3.org/2000/01/rdf-schema#comment | "The actin cytoskeleton dynamically reorganizes the cytoplasm during cell morphogenesis. The actin-related protein (Arp)2/3 complex is a potent nucleator of actin filaments that controls a variety of endomembrane functions including the endocytic internalization of plasma membrane , vacuole biogenesis , plasma-membrane protrusion in crawling cells , and membrane trafficking from the Golgi . Therefore, Arp2/3 is an important signaling target during morphogenesis. The evolutionarily conserved Rac-WAVE-Arp2/3 pathway links actin filament nucleation to cell morphogenesis . WAVE translates Rac-GTP signals into Arp2/3 activation by regulating the stability and/or localization of the activator subunit Scar/WAVE . The WAVE complex includes Sra1/PIR121/CYFIP1, Nap1/NAP125, Abi-1/Abi-2, Brick1(Brk1)/HSPC300, and Scar/WAVE : Defining the in vivo function of each subunit is an important step toward understanding this complicated signaling pathway. Brk1/HSPC300 has been the most recalcitrant WAVE-complex protein and has no known function. In this paper, we report that Arabidopsis brick1 (brk1) is a member of the "distorted group" of trichome morphology mutants, a group that defines a WAVE-ARP2/3 morphogenesis pathway . In this paper we provide the first strong genetic and biochemical evidence that BRK1 is a critical WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2006.03.061"xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/author | "Le J."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/author | "Mallery E.L."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/author | "Szymanski D.B."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/author | "Brankle S."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/name | "Curr Biol"xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/pages | "895-901"xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/title | "Arabidopsis BRICK1/HSPC300 is an essential WAVE-complex subunit that selectively stabilizes the Arp2/3 activator SCAR2."xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://purl.uniprot.org/core/volume | "16"xsd:string |
| http://purl.uniprot.org/citations/16584883 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16584883 |
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