| http://purl.uniprot.org/citations/16595180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16595180 | http://www.w3.org/2000/01/rdf-schema#comment | "Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the cellular signaling mechanism of GCSF-R, yeast two-hybrid system was used to screen a mouse liver library. Here, the interaction of GCSF-R and Snapin was found by yeast two-hybrid experiment, and the interaction of the two proteins was further confirmed by GST pull-down experiment, mammalian two-hybrid experiment and co-immunoprecipitation study. Moreover, the immuno-fluorescence assay was shown that the two proteins of GCSF-R with Snapin were co-localized in the cytoplasm and plasma membrane. The region of C-terminal GCSF-R between box2 and box3, including the residue Tyr703, was responsible for the interaction with Snapin. These data suggested that Snapin is a new interactive protein of GCSF-R."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cyto.2006.01.008"xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/author | "Cong Y."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/author | "Shan Y."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/author | "Yuan X."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/name | "Cytokine"xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/pages | "219-225"xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/title | "Interaction between Snapin and G-CSF receptor."xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/16595180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16595180 |
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