| http://purl.uniprot.org/citations/16596196 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16596196 | http://www.w3.org/2000/01/rdf-schema#comment | "In the current study, we identified paclitaxel-resistant related genes by comparing gene expression profiles of paclitaxel-resistant and parent ovarian cancer cell lines. Gene expression profiles of the human ovarian cancer cell line (KF28), cisplatin-resistant cell line (KFr13) induced from KF28, and paclitaxel-resistant cell lines (KF28TX and KFr13TX) induced by exposing KF28 and KFr13 to dose-escalating paclitaxel were compared and analyzed using cDNA microarray. Of 557 human cancer-related cDNA transcripts compared, 5 genes were found to be underexpressed and 5 genes overexpressed in the paclitaxel-resistant KF28TX, while another paclitaxel-resistant KFr13TX had 5 underexpressed and 8 overexpressed genes. Among these genes, overexpression of the ATP-binding cassette subfamily (MDR-1), Rho guanine dinucleotide phosphate dissociation inhibitor beta (RhoGDI) and insulin-like growth factor binding protein 3 (IGFBP-3) was observed in both paclitaxel-resistant cell lines. Using real-time quantitative PCR, we confirmed the array results. We therefore conclude that IGFBP-3, RhoGDI and MDR-1 were correlated with paclitaxel resistance. Moreover, immunohistochemical staining was analyzed in 22 serous ovarian cancer tissues from patients who received paclitaxel-based chemotherapy, and RhoGDI overexpression was observed more frequently in non-responsers than in responders (p=0.004). RhoGDI expression proved to be a predictive marker of paclitaxel resistance not only in paclitaxel-resistant cell lines, but also in clinical samples."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Goto T."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Kikuchi Y."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Takano M."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Sakamoto M."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Kita T."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Kondo A."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Tsuda H."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Hirata J."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/author | "Tenjin Y."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/pages | "1265-1271"xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/title | "Gene expression profiles with cDNA microarray reveal RhoGDI as a predictive marker for paclitaxel resistance in ovarian cancers."xsd:string |
| http://purl.uniprot.org/citations/16596196 | http://purl.uniprot.org/core/volume | "15"xsd:string |
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