| http://purl.uniprot.org/citations/16596224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16596224 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancer-testis (CT) antigens were identified as a group of highly attractive targets for cancer immunotherapy because of their expression in a variety of malignant tumors but solely in the testis among the normal adult tissues. To evaluate the potential of two members of this family, MAGE-A4 and NY-ESO-1 antigens, for cancer vaccine in non-small cell lung carcinoma (NSCLC), we examined the expression of these antigens and T cell infiltration in tumor tissue, and evaluated their prognostic significance. One hundred fifty-seven patients with NSCLC were studied. Reverse transcription-PCR was performed to evaluate MAGE-A4 and NY-ESO-1 expression. Immunohistochemistry was performed for NY-ESO-1 expression and T cell infiltration into the tumor site. Survival analysis was also performed. MAGE-A4 and NY-ESO-1 were expressed in 40 of 141 (28.4%) and 13 of 157 (8.3%) NSCLC respectively. Both CT antigens were more frequently expressed in squamous cell carcinoma (SCC) than in adenocarcinoma. An inverse correlation was found between MAGE-A4 expression and patient survival in advanced stage cancers. Combined infiltration of both CD4+ and CD8+ T cells into tumor nest predicted better survival. There was no correlation, however, between lymphocyte infiltration and antigen expression in the tumor. MAGE-A4 expression in advanced group and T cell infiltration may provide prognostic information. Lastly, these CT antigens, especially MAGE-A4, may represent potential targets for cancer immunotherapy in patients with NSCLC."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Ikeda H."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Kondo S."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Nishimura T."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Yoshida N."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Miyamoto M."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Morikawa T."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Wakita D."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Ohkuri T."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/author | "Noguchi D."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/pages | "1089-1098"xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/title | "Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance."xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/16596224 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16596224 |
| http://purl.uniprot.org/citations/16596224 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16596224 |
| http://purl.uniprot.org/uniprot/#_B4DTE6-mappedCitation-16596224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16596224 |
| http://purl.uniprot.org/uniprot/#_Q4V9T5-mappedCitation-16596224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16596224 |
| http://purl.uniprot.org/uniprot/#_P43358-mappedCitation-16596224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16596224 |
| http://purl.uniprot.org/uniprot/#_Q1RN33-mappedCitation-16596224 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16596224 |
| http://purl.uniprot.org/uniprot/P43358 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16596224 |