| http://purl.uniprot.org/citations/16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16600855 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been demonstrated that synapses lacking functional synaptotagmin I (Syt I) have a decreased rate of synaptic vesicle endocytosis. Beyond this, the function of Syt I during endocytosis remains undefined. Here, we demonstrate that a decreased rate of endocytosis in syt(null) mutants correlates with a stimulus-dependent perturbation of membrane internalization, assayed ultrastructurally. We then separate the mechanisms that control endocytic rate and vesicle size by mapping these processes to discrete residues in the Syt I C(2)B domain. Mutation of a poly-lysine motif alters vesicle size but not endocytic rate, whereas the mutation of calcium-coordinating aspartate residues (syt-D3,4N) alters endocytic rate but not vesicle size. Finally, slowed endocytic rate in the syt-D3,4N animals, but not syt(null) animals, can be rescued by elevating extracellular calcium concentration, supporting the conclusion that calcium coordination within the C(2)B domain contributes to the control of endocytic rate."xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2006.02.021"xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/author | "Fetter R.D."xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/author | "Davis G.W."xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/author | "Poskanzer K.E."xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/pages | "49-62"xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/title | "Discrete residues in the c(2)b domain of synaptotagmin I independently specify endocytic rate and synaptic vesicle size."xsd:string |
| http://purl.uniprot.org/citations/16600855 | http://purl.uniprot.org/core/volume | "50"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A4V4I8-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |
| http://purl.uniprot.org/uniprot/#_A4V4J0-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |
| http://purl.uniprot.org/uniprot/#_P21521-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |
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| http://purl.uniprot.org/uniprot/#_P27619-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |
| http://purl.uniprot.org/uniprot/#_Q9W0C1-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |
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| http://purl.uniprot.org/uniprot/#_X2J979-mappedCitation-16600855 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16600855 |