| http://purl.uniprot.org/citations/16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16601680 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the human immunodeficiency virus type-1 (HIV-1) promoter in infected cells requires the sequential recruitment of several cellular factors to facilitate the formation of a processive elongation complex. The nucleosomal reorganization of the HIV-1 long terminal repeat (LTR) observed upon Tat stimulation suggests that chromatin-remodeling complexes could play a role during this process. Here, we reported that Tat interacts directly with Brm, a DNA-dependent ATPase subunit of the SWI/SNF chromatin-remodeling complex, to activate the HIV-1 LTR. Inhibition of Brm via small interfering RNAs impaired Tat-mediated transactivation of an integrated HIV-1 promoter. Furthermore, Brm is recruited in vivo to the HIV-1 LTR in a Tat-dependent manner. Interestingly, we found that Tat/Brm interaction is regulated by Tat lysine 50 acetylation. These data show the requirement of Tat-mediated recruitment of SWI/SNF chromatin-remodeling complex to HIV-1 promoter in the activation of the LTR."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7601074"xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Benarous R."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Benkirane M."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Emiliani S."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Bres V."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Treand C."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "Kiernan R."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/author | "du Chene I."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/pages | "1690-1699"xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/title | "Requirement for SWI/SNF chromatin-remodeling complex in Tat-mediated activation of the HIV-1 promoter."xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16601680 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16601680 |
| http://purl.uniprot.org/citations/16601680 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16601680 |
| http://purl.uniprot.org/uniprot/#_Q12824-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_O60563-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_P50750-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_P04326-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_Q09472-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_P51531-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_Q92922-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |
| http://purl.uniprot.org/uniprot/#_Q8TAQ2-mappedCitation-16601680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16601680 |