| http://purl.uniprot.org/citations/16604061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16604061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16604061 | http://www.w3.org/2000/01/rdf-schema#comment | "Dishevelled (Dvl) transduces signals from the Wnt receptor, Frizzled, to downstream components, leading to the stabilization of beta-catenin and subsequent activation of the transcription factor T cell factor (TCF) and/or lymphoid enchancer factor (LEF). However, the mechanism of Dvl action remains unclear. Here, we report that nucleoredoxin (NRX), a thioredoxin (TRX) family protein, interacts with Dvl. Overexpression of NRX selectively suppresses the Wnt-beta-catenin pathway and ablation of NRX by RNA-interference (RNAi) results in activation of TCF, accelerated cell proliferation and enhancement of oncogenicity through cooperation with mitogen-activated extracellular signal regulated kinase kinase (MEK) or Ras. We find that cells respond to H(2)O(2) stimulation by activating TCF. Redox-dependent activation of the Wnt-beta-catenin pathway occurs independently of extracellular Wnts and is impaired by RNAi of NRX . In addition, association between Dvl and NRX is inhibited by H(2)O(2) treatment. These data suggest a relationship between the Wnt-beta-catenin pathway and redox signalling through redox-sensitive association of NRX with Dvl."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1405"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1405"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Miki H."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Asashima M."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Asashima M."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Michiue T."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Michiue T."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Funato Y."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/author | "Funato Y."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/name | "Nat. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/pages | "501-508"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/pages | "501-508"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/title | "The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/title | "The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt-beta-catenin signalling through dishevelled."xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/16604061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16604061 |
| http://purl.uniprot.org/citations/16604061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16604061 |