| http://purl.uniprot.org/citations/16606668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16606668 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy and asthma after inappropriate activation. We demonstrate that il25(-/-) mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells. We further establish a key role for interleukin (IL)-25 in regulating a novel population of IL-4-, IL-5-, IL-13-producing non-B/non-T (NBNT), c-kit+, FcepsilonR1-cells during helminth infection. A deficit in this population in il25(-/-) mice correlates with inefficient N. brasiliensis expulsion. In contrast, administration of recombinant IL-25 in vivo induces the appearance of NBNT, c-kit+, FcepsilonR1-cells and leads to rapid worm expulsion that is T and B cell independent, but type 2 cytokine dependent. We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20051615"xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Dasvarma A."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "McKenzie A.N."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Hewett D.R."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Mangan N.E."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Fallon P.G."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Jolin H.E."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Ballantyne S.J."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "Barlow J.L."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/author | "McIlgorm A."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/pages | "1105-1116"xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/title | "Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion."xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://purl.uniprot.org/core/volume | "203"xsd:string |
| http://purl.uniprot.org/citations/16606668 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16606668 |
| http://purl.uniprot.org/citations/16606668 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16606668 |
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| http://purl.uniprot.org/uniprot/#_P20109-mappedCitation-16606668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16606668 |
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| http://purl.uniprot.org/uniprot/#_P04401-mappedCitation-16606668 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16606668 |