DESCRIBE <http://purl.uniprot.org/citations/16608517>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16608517	http://www.w3.org/2000/01/rdf-schema#comment	" Background Ribosomal proteins are the components of ribosome, which also exhibit various secondary functions in DNA repair, apoptosis, drug resistance and proliferation. In our previous study of microarray, ribosomal protein L15 (RPL15) was identified as an upregulated gene in gastric cancer. Methods We investigated the expression of ribosomal protein L15 in gastric cancer and the effect of RPL15 on proliferation of gastric cancer. Results It was found that the expression of RPL15 was markedly up-regulated in gastric cancer tissues. RPL15 was also highly expressed in gastric cancer cell lines AGS, MKN45, MKN28, SGC7901 and KATOIII. Inhibition of RPL15 expression by siRNA vector transfection suppressed the growth of SGC7901 cells significantly, which was independent of the expression of Cyclin D1 and B1. Down-regulation of RPL15 expression inhibited SGC7901 cell growth in soft agar and its tumorigenicity in nude mice. Conclusion RPL15 promotes cell proliferation and may be a potential target for anticancer therapy of gastric cancer."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.org/dc/terms/identifier	"doi:10.1186/1471-2407-6-91"xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Ling R."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Wang L."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Wang H."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Li X.J."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Zhao L.N."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/author	"Li K.Z."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/date	"2006"xsd:gYear
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/name	"BMC Cancer"xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/pages	"91"xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/title	"Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer."xsd:string
http://purl.uniprot.org/citations/16608517	http://purl.uniprot.org/core/volume	"6"xsd:string
http://purl.uniprot.org/citations/16608517	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16608517
http://purl.uniprot.org/citations/16608517	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16608517
http://purl.uniprot.org/uniprot/#_B4DEN1-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_B4DLP4-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_P61313-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_Q5M8Q0-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_Q3U7D2-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_Q76N55-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/#_Q9CZM2-mappedCitation-16608517	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/Q9CZM2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16608517
http://purl.uniprot.org/uniprot/B4DLP4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16608517