| http://purl.uniprot.org/citations/16611243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16611243 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16611243 | http://www.w3.org/2000/01/rdf-schema#comment | "Septic injury triggers a rapid and widespread response in Drosophila adults that involves the up-regulation of many genes required to combat infection and for wound healing. Genome-wide expression profiling has already demonstrated that this response is controlled by signaling through the Toll, Imd, JAK-STAT and JNK pathways. Using oligonucleotide microarrays, we now demonstrate that the MAPKKK Mekk1 regulates a small subset of genes induced by septic injury including Turandot (Tot) stress genes. Our analysis indicates that Tot genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1. Interestingly, Mekk1 flies are resistant to microbial infection but susceptible to paraquat, an inducer of oxidative stress. These results point to a role of Mekk1 in the protection against tissue damage and/or protein degradation and indicate complex interactions between stress and immune pathways in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2006.00953.x"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2443.2006.00953.x"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Lemaitre B."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Lemaitre B."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Takahashi K."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Vidal S."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Vidal S."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Tricoire H."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Tricoire H."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Brun S."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Brun S."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Spellman P."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/author | "Spellman P."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/name | "Genes Cells"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/pages | "397-407"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/pages | "397-407"xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/title | "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16611243 | http://purl.uniprot.org/core/title | "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila."xsd:string |