| http://purl.uniprot.org/citations/16616331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16616331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16616331 | http://www.w3.org/2000/01/rdf-schema#comment | "AML1/ETO is the chimeric protein resulting from the t(8;21) in acute myeloid leukemia. The Nervy homology 2 (NHR2) domain in ETO mediates oligomerization and AML1/ETO's interactions with ETO, MTGR1, and MTG16, and with the corepressor molecules mSin3A and HDAC1 and HDAC3. We solved the NHR2 domain structure and found it to be an alpha-helical tetramer. We show that oligomerization contributes to AML1/ETO's inhibition of granulocyte differentiation, is essential for its ability to enhance the clonogenic potential of primary mouse bone marrow cells, and affects AML1/ETO's activity on several endogenous genes. Oligomerization is also required for AML1/ETO's interactions with ETO, MTGR1, and MTG16, but not with other corepressor molecules."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2006.03.012"xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2006.03.012"xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Chruszcz M."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Chruszcz M."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Dauter Z."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Dauter Z."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Minor W."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Minor W."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Cole J."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Cole J."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Bushweller J.H."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Bushweller J.H."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Sugiyama D."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Sugiyama D."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Lukasik S.M."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Lukasik S.M."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Cheney M.D."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Cheney M.D."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Gaudet J.J."xsd:string |
| http://purl.uniprot.org/citations/16616331 | http://purl.uniprot.org/core/author | "Gaudet J.J."xsd:string |